Age Related Protein Carbonylation In Different Organs Of Common Asian Toad, Duttaphrynus Melanostictus

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D. D. Sahoo and T.C. Kara

P.G. Dept. of Life Sciences, S.K.C.G.(Auton.) College, Paralakhemundi-761200, Odisha, India

195/196, Krishnapuri, Near IIIT, Bhubaneswar-751003, Odisha, India.

Protein carbonylation measured in terms of nano moles of 2, 4-DNPH incorporated /mg protein was found increasing significantly (p < 0.001) with advancing age in liver, kidney and brain of common Asian toad, Duttaphrynus melanostictus. There was significant positive correlation between carbonylated protein in different organs studied and increasing age of the animals. Liver showed highest, brain moderate and kidney with lower level of carbonylation in protein molecules. Since different organs were with different level of protein carbonylation, it appears some selected protein molecules are likely to be more carbonylated than others. Common Asian toads being ectothermic animals showed similar age related increasing trend of protein carbonylation like their endothermic mammalian counterpart indicating a common mechanism of accumulation of modified proteins during ageing.

 

Keywords : Ageing; Antioxidant; Lipid Peroxidation; protein oxidation; Proteasome; ROS.

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