Alterations in Pro-Oxidant and Antioxidant Status In Different age Groups of Cadmium Exposed Male Common Indian Toads, Bufo Melanostictus

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D.D. Sahoo and T.C. Kara

P.G Department of Life Sciences, S. K. C. G(Autonomous) College, Paralakhemundi , Gajapati, Odisha, India  195/196, Krishnapuri Near IIIT, Bhubaneswar-751003, Odisha, India

The present study aims to investigate the prooxidant and antioxidant status in different age groups of Cadmium treated (Single dose of CdCl2, 2.5 m g/g body weight, i. p.) male common Indian toads, Bufo melanostictus (presently Duttaphrynus melanostictus).  In this study a significant increase in lipid peroxidation (LPO) Potential in the liver tissue of all the three age groups (young, middle aged and old) of Cadmium treated animal was found. The rate of elevation in LPO potential was found to increase with advancing age. A significant decrease in enzymatic antioxidant like superoxide dismutase (SOD) and Catalase (CAT) was found in liver of all the three age groups of toads exposed to Cadmium than their control counter parts. However the degree of inhibition of SOD and catalase was more pronounced in the old aged toads than that of the middle aged ones. Similarly cadmium treatment significantly declined the non-enzymatic antioxidant, Ascorbic acid (ASA) and Uric Acid (UA) status in liver tissue of all the three age groups of toads than that of their control untreated counterparts. The degree of depletion of ascorbic acid (ASA) and uric acid (UA) due to Cadmium treatment was minimum during maturation phase as compared to their younger and older counter parts. Therefore a more efficient antioxidant defense against the pro-oxidants due to cadmium treatment was found in the middle aged group of animals than that of their younger and older counter parts.

 

Key Words :  Ascorbic acid; Catalase; CdCl2; Glutathione; Lipid peroxidation; Reactive oxygen species; SOD; Uric acid.

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