Effect of leptin resistance on body weight regulation in pregnant Apodemus chevrieri

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Ting Jia, Wanlong Zhu

                              Department of pharmacy, Yunnan Medical Health College, Kunming 650106, China

In order to clarify whether the Apodemus chevrieri has leptin resistance during pregnancy. The body weight, food intake, fat weight and serum leptin concentration of 12 adult female A. chevrieri were measured. The results showed that the body weight, food intake and serum leptin concentration of pregnant A. chevrieri were significantly higher than those of non-pregnant A. chevrieri. Serum leptin concentration was positively correlated with body weight and fat content. The results indicated that there might be leptin resistance in pregnant A. chevrieri, which allowed the body weight adjustment point to rise and adapt to the increase of energy demand during pregnancy.

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