Department of Biological Science & Engineering, Maulana Azad National Institute of Technology, Bhopal,                                           Madhya Pradesh-462003 (India)

Snakebite causes the highest rate of injury and among the population, especially in Asian countries. Snake venom is a type of zootoxins composed of a highly complex mixture of enzymes including phospholipase A₂, hyaluronidase, L-amino acid oxidase, acetylcholine esterase, phosphodiester, and low molecular weight polypeptide. The hyaluronidase or hyaluronic glucosidase venom enzyme is considered a “spreading factor” as it hydrolyzes the hyaluronic acid (generally known as hyaluronan), which plays an essential role of cell to cell adhesion in the extracellular matrix of tissue. Secondary metabolites present in a crude extract of medicinal plants are considered as capable venom neutralizing agents as they have no side effect and can neutralize a wide range of snake venom enzymes. The objective of this review is to collect, simplify and explain the role along with the importance of inhibition of hyaluronic glucosidase in snake venoms. All the accessible information on hyaluronic glucosidases was collected via electronic search (using Google Books, PubMed, SciFinder, Scopus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. This review contains a brief description of the structure, occurrence, mechanism, assay procedures, and phytoconstituents reported to inhibit hyaluronidase.