Pure silver nanoparticles showed potential anticancer effect on colon and breast cancer cell lines

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Mohd Salim Reshi, Gaurav Bhatia, Deepa Yadav, Chhavi Uthra, Sadhana Shrivastava Jatinder Singh Arora and Sangeeta Shukla

UNESCO- Trace Element Satellite Center School of Studies in Zoology, Jiwaji University, Gwalior (M.P). India

Protein Lab, Department of Biochemistry and Molecular Biology, Guru Nanak Dev University, Amritsar

 

Present study was designed to investigate the anticancer potential of silver nanoparticles (AgNPs) on Human cancer cell lines (MCF-7 & HCT-15). AgNPs showed a dose-dependent toxicity towards both the cell lines. AgNPs decreased the viability of tested cells to 50% at 24.44ppm for MCF-7& 12.89ppm for HCT-15 cells respectively. Percent cytotoxicity of AgNPs was determined by Lactate dehydrogenase (LDH) Assay. LDH activities in medium of AgNPs treated cells were found to be significantly elevated on both the cell lines as compared to the non treated cells. This study revealed that AgNPs demonstrate strong anticancer potential on MCF-7 and HCT-15, however more effect was observed on MCF-7 than HCT-15 cell.

 

 

Key words: Silver nanoparticles,MCF-7, HCT-15, Anticancer

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