A Review On Artemisinins: Discovery, Mechanism Of Action And Importance In Medicine

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Rama Raju Baadhe, Naveen Kumar Mekala, Sreenivasa Rao Parcha

            Department of Biotechnology, National Institute of Technology, Warangal, India

 Clinical Reseearch Facility lab , Centre for Cellular and Molecular Biology, Tarnaka, Hyderabad, India

 Artemisinin is an isoprenoid produced in Artemisia annua whichis a common type of wormwood that is native to temperate Asia, but adopted throughout the world. Artemisinin was well-known for its antimalarial activity, which is an overwhelming human disease in the tropical areas, which threatens 300–500 million people and kills approximately two million people annually and ranked in the top three of communicable diseases. World Health Organization recommended the Artemisinin-based combination therapies (ACTs) for preventing malaria which augmented the inevitability of artemisinin. Artemisinin limitations like low solubility and low bioavabilty conquer by its derivates collectively known as ‘artemisinins’. The focal point of this sharp review explains about the discovery, advanced applications and mechanism of action of artemisinins in treatment of malaria, cancer, viruses and other protozoan parasites.

Keywords: Artemisinins, Endoperoxide Bridge, Antimalarial avctivity, Artemisinin-based Combination Therapies (ACTs). 

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