Role of hypothalamic neuropeptides genes expression on body mass regulation under food restriction in Eothenomys miletus

  • strict warning: Non-static method view::load() should not be called statically in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/views.module on line 1113.
  • strict warning: Declaration of views_handler_field::query() should be compatible with views_handler::query($group_by = false) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_field.inc on line 1147.
  • strict warning: Declaration of content_handler_field::element_type() should be compatible with views_handler_field::element_type($none_supported = false, $default_empty = false, $inline = false) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/cck/includes/views/handlers/content_handler_field.inc on line 229.
  • strict warning: Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_filter.inc on line 587.
  • strict warning: Declaration of views_handler_filter::query() should be compatible with views_handler::query($group_by = false) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_filter.inc on line 587.
  • strict warning: Declaration of views_handler_filter_search::exposed_validate() should be compatible with views_handler::exposed_validate(&$form, &$form_state) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/modules/search/views_handler_filter_search.inc on line 112.
  • strict warning: Declaration of views_handler_area::query() should be compatible with views_handler::query($group_by = false) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_area.inc on line 81.
  • strict warning: Declaration of views_handler_area_text::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_area_text.inc on line 121.
  • strict warning: Non-static method view::load() should not be called statically in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/views.module on line 1113.
  • strict warning: Declaration of views_handler_sort::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_sort.inc on line 165.
  • strict warning: Declaration of views_handler_sort::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_sort.inc on line 165.
  • strict warning: Declaration of views_handler_sort::query() should be compatible with views_handler::query($group_by = false) in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/handlers/views_handler_sort.inc on line 165.
  • strict warning: Non-static method view::load() should not be called statically in /home/u809185268/domains/sciencebeingjournal.com/public_html/sites/all/modules/views/views.module on line 1113.
Wan-Long Zhu and Gaung Yang

Key Laboratory of Ecological Adaptive Evolution and Conservation on Animals-Plants in Southwest Mountain Ecosystem of Yunnan Province Higher Institutes College, School of Life Science of Yunnan Normal University, Kunming; 650500, China;

          College of Life Sciences of Nanjing Normal University, Nanjing 210023, China

The present study was aimed at examining the role of hypothalamic neuropeptides genes expression on body mass regulation under food restriction in Eothenomys miletus, body mass, food intake, serum leptin levels and hypothalamic neuropeptide Neuropeptide Y (NPY), Agouti Aelated Peptide (AgRP), Pro-opiomelanocortin (POMC), Cocaine and Amphetamine Regulated Transcript (CART) expressions were measured. Food restriction reduced body mass and body fat mass, and increased food intake. Serum leptin levels showed significant differences between control group and food restriction group, and leptin levels showed a positive correlation with body fat mass. Hypothalamic neuropeptide NPY, AgRP, POMC and CART expression showed significant different between two groups. Leptin was negatively correlated with NPY and AgRP, and positively correlated with CART and POMC.All of the results suggested that food restriction can reduce the body mass, body fat mass and leptin levels, increased food intake and hypothalamic neuropeptide expressions. Leptin may play an regulation on body mass and energy metabolism by acting on hypothalamic neuropeptide of NPY/AgRP and CART/CART pathways in E. miletus.

Keywords: Eothenomys miletus; Hypothalamic neuropeptides; Body mass; Food restriction

 

 

application/pdf icon| PDF (1 MB) |