Advanced Genomics Institute & Laboratory Medicine (AGILE), New Delhi, India

It has been suggested that the fluoridation of drinking water and the prevalence of Down syndrome are positively correlated. Young women are believed to exhibit this link the most. Many researchers worked and found out that there is some relation between Down syndrome births and fluoridation. Hence, the data on congenital abnormalities were examined from various resources. According to some studies, the problem was with water sources as these were found to be fluoridated and, in some cities, these had inadequate fluoride levels. In cities with fluoridated water supplies and those without, the prevalence of Down syndrome was comparable. Furthermore, some studies suggested that there was no evidence for a relationship particular to maternal age. The objective of this review is to look at the data supporting a link between Down's syndrome and water fluoride levels.