Studies of Novel Thiazole-Imidazole Combined Molecule

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Purvesh J. Shah

            Department of Chemistry, Shree P. M. Patel Institute of P. G. Studies and Research in Science, Anand-388001

The condensation reaction of 4-benzylidene-2-p-tolyloxazol-5(4H)-one(2) with 2-amino substituted benzothiazole3(I-VI) was yielded a series of 4-benzylidene-1-(substitued-2-benzo thiazolyl)-2-(4-methoxyphenyl)-1H-imidazol-5(4H)-one 4(I-VI).The 4-benzylidene-2-p-tolyloxazol-5(4H)-one(2) has been prepared from cyclo condensation reaction between hippuric acid (1) with p-methyl benzaldehyde. The novel prepared compounds were characterized by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the prepared compounds were screened for their antibacterial activities and antifungal activities.

Keywords: 2-amino benzthiazole; Antibacterial activities; Antifungal activities; Imidazole.

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